Production and Purification of High-Titer Newcastle Disease Virus for Use in Preclinical Mouse Models of Cancer
Newcastle disease virus (NDV) is a single-stranded, negative-sense RNA virus in the Paramyxoviridae family.Although primarily an avian pathogen, NDV is a potent oncolytic virus that has been shown jmannino.com to be safe and effective in a variety of preclinical cancer models and human clinical trials.To produce virus for oncolytic trials, NDV is c